Glioma Virotherapy: The Effects of Innate Immune Suppression and Increased Viral Replication Capacity
نویسندگان
چکیده
Oncolytic viruses are genetically altered replication-competent viruses which infect, and reproduce in, cancer cells but do not harm normal ∗Corresponding author: Mathematical Biosciences Institute, The Ohio State University, 18th Avenue, Columbus OH 43210, USA. E-mail address: [email protected].
منابع مشابه
Glioma virotherapy: effects of innate immune suppression and increased viral replication capacity.
Oncolytic viruses are genetically altered replication-competent viruses that infect, and reproduce in, cancer cells but do not harm normal cells. On lysis of the infected cells, the newly formed viruses burst out and infect other tumor cells. Experiments with injecting mutant herpes simplex virus 1 (hrR3) into glioma implanted in brains of rats show lack of efficacy in eradicating the cancer. T...
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